From bulk, single-cell to spatial RNA sequencing.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

引用：Li X, Wang CY. (2021). From bulk, single-cell to spatial RNA sequencing. International journal of oral science. PMID 34782601 · PMC8593179 · DOI 10.1038/s41368-021-00146-0

证据类型：REVIEW

主题：rna-seq、single-cell

被引次数（采集时）：434

原始记录：[Europe PMC](https://europepmc.org/article/MED/34782601)

来源许可：[CC-BY](https://creativecommons.org/licenses/by/)

作者摘要（按来源许可复用）

RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology.

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