Fast alignment and preprocessing of chromatin profiles with Chromap.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

引用：Zhang H, Song L, Wang X, Cheng H, Wang C, Meyer CA, Liu T, Tang M, Aluru S, Yue F, Liu XS, Li H. (2021). Fast alignment and preprocessing of chromatin profiles with Chromap. Nature communications. PMID 34772935 · PMC8589834 · DOI 10.1038/s41467-021-26865-w

证据类型：PRIMARY_RESEARCH

主题：epigenomics

被引次数（采集时）：182

原始记录：[Europe PMC](https://europepmc.org/article/MED/34772935)

来源许可：[CC-BY](https://creativecommons.org/licenses/by/)

作者摘要（按来源许可复用）

As sequencing depth of chromatin studies continually grows deeper for sensitive profiling of regulatory elements or chromatin spatial structures, aligning and preprocessing of these sequencing data have become the bottleneck for analysis. Here we present Chromap, an ultrafast method for aligning and preprocessing high throughput chromatin profiles. Chromap is comparable to BWA-MEM and Bowtie2 in alignment accuracy and is over 10 times faster than traditional workflows on bulk ChIP-seq/Hi-C profiles and than 10x Genomics' CellRanger v2.0.0 pipeline on single-cell ATAC-seq profiles.

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