Dynamic transcriptomic m 6 A decoration: writers, erasers, readers and functions in RNA metabolism.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

引用：Yang Y, Hsu PJ, Chen YS, Yang YG. (2018). Dynamic transcriptomic m 6 A decoration: writers, erasers, readers and functions in RNA metabolism. Cell research. PMID 29789545 · PMC5993786 · DOI 10.1038/s41422-018-0040-8

证据类型：REVIEW

主题：rna-seq

被引次数（采集时）：1320

原始记录：[Europe PMC](https://europepmc.org/article/MED/29789545)

来源许可：[CC-BY](https://creativecommons.org/licenses/by/)

作者摘要（按来源许可复用）

N 6 -methyladenosine (m 6 A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m 6 A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m 6 A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

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