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Multi-Omics of Single Cells: Strategies and Applications.

Most genome-wide assays provide averages across large numbers of cells, but recent technological advances promise to overcome this limitation. Pioneering single-cell assays are now available for genome, epigenome, transcriptome, proteome, and metabolome profiling. Here, we describe how these different dimensions can be combined into multi-omics assays that provide comprehensive profiles of the same cell.

Multi-Omics of Single Cells: Strategies and Applications.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

  • 引用:Bock C, Farlik M, Sheffield NC. (2016). Multi-Omics of Single Cells: Strategies and Applications. Trends in biotechnology. PMID 27212022 · PMC4959511 · DOI 10.1016/j.tibtech.2016.04.004
  • 证据类型:REVIEW
  • 主题:single-cell、epigenomics、proteomics、metabolomics、multi-omics
  • 被引次数(采集时):109
  • 原始记录:[Europe PMC](https://europepmc.org/article/MED/27212022)
  • 来源许可:[CC-BY](https://creativecommons.org/licenses/by/)
  • 作者摘要(按来源许可复用)

    Most genome-wide assays provide averages across large numbers of cells, but recent technological advances promise to overcome this limitation. Pioneering single-cell assays are now available for genome, epigenome, transcriptome, proteome, and metabolome profiling. Here, we describe how these different dimensions can be combined into multi-omics assays that provide comprehensive profiles of the same cell.

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    Multi-Omics of Single Cells: Strategies and Applications. · GeniOmics