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Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice.

Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.

Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

  • 引用:Tafazoli A, Guchelaar HJ, Miltyk W, Kretowski AJ, Swen JJ. (2021). Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice. Frontiers in pharmacology. PMID 34512329 · PMC8424415 · DOI 10.3389/fphar.2021.693453
  • 证据类型:REVIEW
  • 主题:clinical-genomics
  • 被引次数(采集时):38
  • 原始记录:[Europe PMC](https://europepmc.org/article/MED/34512329)
  • 来源许可:[CC-BY](https://creativecommons.org/licenses/by/)
  • 作者摘要(按来源许可复用)

    Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.

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