A Critical Review of Bottom-Up Proteomics: The Good, the Bad, and the Future of this Field.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

引用：Dupree EJ, Jayathirtha M, Yorkey H, Mihasan M, Petre BA, Darie CC. (2020). A Critical Review of Bottom-Up Proteomics: The Good, the Bad, and the Future of this Field. Proteomes. PMID 32640657 · PMC7564415 · DOI 10.3390/proteomes8030014

证据类型：REVIEW

主题：proteomics

被引次数（采集时）：242

原始记录：[Europe PMC](https://europepmc.org/article/MED/32640657)

来源许可：[CC-BY](https://creativecommons.org/licenses/by/)

作者摘要（按来源许可复用）

Proteomics is the field of study that includes the analysis of proteins, from either a basic science prospective or a clinical one. Proteins can be investigated for their abundance, variety of proteoforms due to post-translational modifications (PTMs), and their stable or transient protein-protein interactions. This can be especially beneficial in the clinical setting when studying proteins involved in different diseases and conditions. Here, we aim to describe a bottom-up proteomics workflow from sample preparation to data analysis, including all of its benefits and pitfalls. We also describe potential improvements in this type of proteomics workflow for the future.

合规说明

本页保存的是来源文献书目信息及其在 CC-BY 许可下公开的作者摘要。除去除来源 HTML 标签和规范化空白外，摘要未作内容改写。本页不代表 GeniOmics 的医学建议；原文版权、署名和许可仍归原权利人，请通过原始记录核对最新版本、更正或撤稿状态。