Public knowledge document

UCell: Robust and scalable single-cell gene signature scoring.

UCell is an R package for evaluating gene signatures in single-cell datasets. UCell signature scores, based on the Mann-Whitney U statistic, are robust to dataset size and heterogeneity, and their calculation demands less computing time and memory than other available methods, enabling the processing of large datasets in a few minutes even on machines with limited computing power. UCell can be applied to any single-cell data matrix, and includes functions to directly interact with Seurat objects. The UCell package and documentation are available on GitHub at https://github.com/carmonalab/UCell.

UCell: Robust and scalable single-cell gene signature scoring.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

  • 引用:Andreatta M, Carmona SJ. (2021). UCell: Robust and scalable single-cell gene signature scoring. Computational and structural biotechnology journal. PMID 34285779 · PMC8271111 · DOI 10.1016/j.csbj.2021.06.043
  • 证据类型:PRIMARY_RESEARCH
  • 主题:single-cell
  • 被引次数(采集时):991
  • 原始记录:[Europe PMC](https://europepmc.org/article/MED/34285779)
  • 来源许可:[CC-BY](https://creativecommons.org/licenses/by/)
  • 作者摘要(按来源许可复用)

    UCell is an R package for evaluating gene signatures in single-cell datasets. UCell signature scores, based on the Mann-Whitney U statistic, are robust to dataset size and heterogeneity, and their calculation demands less computing time and memory than other available methods, enabling the processing of large datasets in a few minutes even on machines with limited computing power. UCell can be applied to any single-cell data matrix, and includes functions to directly interact with Seurat objects. The UCell package and documentation are available on GitHub at https://github.com/carmonalab/UCell.

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    UCell: Robust and scalable single-cell gene signature scoring. · GeniOmics